Lecture 14

May 14, 2008

Regulation: types and 2 component model

1. review purpose of regulation

change cell composition

• but, directed change without a goal
• optimization as a product

deal with variations in resources

balance metabolism flow

other

• protection
• prediction/control
• time

2. Regulation levels

levels, context and mechanism

in a pathway

• on-off
• graded

gene expression

3. Two component model

enzyme act/inact

protein synthesis