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Selected Publications

  1. Strongin, R. M.; Sharma, E.; Erythropel, H. C.; El-Hellani, A.; Kassem, N. O. F.; Mikheev, V. B.; Noël, A.; Peyton, D. H.; Springer, M. L. "Emerging ENDS products and challenges in tobacco control toxicity research," Tob. Control, (2022). doi:10.1136/tobaccocontrol-2022-057268.

  2. Munger, K. R.; Jensen, R. P.; Strongin, R. M. "Vaping Cannabinoid Acetates Leads to Ketene Formation," Chem. Res. Toxicol., 35, 1202-1205, (2022). doi:10.1021/acs.chemrestox.2c00170.

  3. Word, T. A.; Quick, A. P.; Miyake, C. Y.; Shak, M. K.; Pan, X.; Kim, J. J.; Allen, H. D.; Sibrian-Vazquez, M.; Strongin, R. M.; Landstrom, A. P.; Wehrens, X. H. T. "Efficacy of RyR2 inhibitor EL20 in induced pluripotent stem cell-derived cardiomyocytes from a patient with catecholaminergic polymorphic ventricular tachycardia," J. Cell. Mol. Med., 25, 6115-6124, (2021). doi:10.1111/jcmm.16521.

  4. Gupta, M.; Meehan-Atrash, J.; Strongin, R. M. "Identifying a role for the interaction of homocysteine and copper in promoting cardiovascular-related damage," Amino Acids, (2021). doi:10.1007/s00726-021-02979-9.

  5. Meehan-Atrash, J.; Luo, W.; McWhirter, K. J.; Dennis, D. G.; Sarlah, D.; Jensen, R. P.; Afreh, I.; Jiang, J.; Barsanti, K. C.; Ortiz, A.; Strongin, R. M. "The influence of terpenes on the release of volatile organic compounds and active ingredients to cannabis vaping aerosols," RSC Advances, 11, 11714-11723, (2021). doi:10.1039/D1RA00934F.

  6. Mafireyi, T. J.; Escobedo, J. O.; Strongin, R. M. "Fluorogenic probes for thioredoxin reductase activity," Results Chem., 3, 100127, (2021). doi:10.1016/j.rechem.2021.100127.

  7. Strongin, R. M. "Toxic ketene gas forms on vaping vitamin E acetate prompting interest in its possible role in the EVALI outbreak," Proc. Natl. Acad. Sci. U. S. A., 117, 7553-7554, (2020). doi:10.1073/pnas.2003384117.

  8. Meehan-Atrash, J.; Strongin, R. M. "Pine rosin identified as a toxic cannabis extract adulterant," Forensic Sci. Int., 312, 110301, (2020). doi:10.1016/j.forsciint.2020.110301.

  9. Vreeke, S.; Zhu, X.; Strongin, R. M. "A simple predictive model for estimating relative e-cigarette toxic carbonyl levels," PLoS ONE, 15, e0238172, (2020). doi:10.1371/journal.pone.0238172.

  10. Mafireyi, T. J.; Laws, M.; Bassett, J. W.; Cassidy, P. B.; Escobedo, J. O.; Strongin, R. M. "A Diselenide Turn-On Fluorescent Probe for the Detection of Thioredoxin Reductase," Angew. Chem., Int. Ed., 59, 15147-15151, (2020). doi:10.1002/anie.202004094.

  11. Meehan-Atrash, J.; Luo, W.; McWhirter, K. J.; Strongin, R. M. "Aerosol Gas-Phase Components from Cannabis E-Cigarettes and Dabbing: Mechanistic Insight and Quantitative Risk Analysis," ACS Omega, (2019). doi:10.1021/acsomega.9b02301.

  12. Yue, Y.; Huo, F.; Cheng, F.; Zhu, X.; Mafireyi, T.; Strongin, R. M.; Yin, C. "Functional synthetic probes for selective targeting and multi-analyte detection and imaging," Chem. Soc. Rev., 48, 4155-4177, (2019). doi:10.1039/C8CS01006D.

  13. Munhenzva, I. R.; Barth, C. W.; Sibrian-Vazquez, M.; Wang, L. G.; Escobedo, J. O.; Gibbs, S. L.; Strongin, R. M. "Assessment of human pancreas cancer tissue and precursor lesions via a fluorophore with inherent PDAC selectivity," Methods (2019). doi:10.1016/j.ymeth.2019.06.008.

  14. Strongin, R. M. "E-Cigarette Chemistry and Analytical Detection," Annu. Rev. Anal. Chem., 12, 23-39, (2019). doi:10.1146/annurev-anchem-061318-115329.

  15. Wang, L. G.; Munhenzva, I.; Sibrian-Vázquez, M.; Escobedo, J. O.; Kitts, C. H.; Fronczek, F. R.; Strongin, R. M. "Altering Fundamental Trends in the Emission of Xanthene Dyes," J. Org. Chem., 84, 2585-2595 (2019). doi:10.1021/acs.joc.8b03030.

  16. Korzun, T.; Munhenzva, I.; Escobedo, J. O.; Strongin, R. M. "Synthetic food dyes in electronic cigarettes," Dyes Pigm., 160, 509-513 (2018). doi:10.1016/j.dyepig.2018.08.043.

  17. Vreeke, S.; Peyton, D. H.; Strongin, R. M. "Triacetin Enhances Levels of Acrolein, Formaldehyde Hemiacetals, and Acetaldehyde in Electronic Cigarette Aerosols," ACS Omega, 3, 7165-7170, (2018). doi:10.1021/acsomega.8b00842.

  18. Yue, Y.; Huo, F.; Yue, P.; Meng, X.; Salamanca, J. C.; Escobedo, J. O.; Strongin, R. M.; Yin, C. "In Situ Lysosomal Cysteine-Specific Targeting and Imaging during Dexamethasone-Induced Apoptosis," Anal. Chem., 90, 7018-7024, (2018). doi:10.1021/acs.analchem.8b01406.

  19. Salamanca, J. C.; Meehan-Atrash, J.; Vreeke, S.; Escobedo, J. O.; Peyton, D. H.; Strongin, R. M. "E-cigarettes can emit formaldehyde at high levels under conditions that have been reported to be non-averse to users," Sci. Rep., 8, 7559, (2018). doi:10.1038/s41598-018-25907-6.

  20. Bittel, A. M.; Davis, A. M.; Wang, L.; Nederlof, M. A.; Escobedo, J. O.; Strongin, R. M.; Gibbs, S. L. "Varied Length Stokes Shift BODIPY-Based Fluorophores for Multicolor Microscopy," Sci. Rep., 8, 4590, (2018). doi:10.1038/s41598-018-22892-8.

  21. Korzun, T.; Lazurko, M.; Munhenzva, I.; Barsanti, K. C.; Huang, Y.; Jensen, R. P.; Escobedo, J. O.; Luo, W.; Peyton, D. H.; Strongin, R. M. "E-Cigarette Airflow Rate Modulates Toxicant Profiles and Can Lead to Concerning Levels of Solvent Consumption," ACS Omega, 3, 30-36, (2018). doi:10.1021/acsomega.7b01521.

  22. Vreeke, S.; Korzun, T.; Luo, W.; Jensen, R. P.; Peyton, D. H.; Strongin, R. M. "Dihydroxyacetone Levels in Electronic Cigarettes: Wick Temperature and Toxin Formation," Aerosol Sci. Technol., 52, 370-376, (2018). doi:10.1080/02786826.2018.1424316.

  23. Meehan-Atrash, J.; Luo, W.; Strongin, R. M. "Toxicant Formation in Dabbing: The Terpene Story," ACS Omega, 2, 6112-6117, (2017). doi:10.1021/acsomega.7b01130.

  24. Salamanca, J. C.; Munhenzva, I.; Escobedo, J. O.; Jensen, R. P.; Shaw, A.; Campbell, R.; Luo, W.; Peyton, D. H.; Strongin, R. M. "Formaldehyde Hemiacetal Sampling, Recovery, and Quantification from Electronic Cigarette Aerosols," Sci. Rep., 7, 11044, (2017). doi:10.1038/s41598-017-11499-0.

  25. Strongin, R. M.; Escobedo, J. O. "Sensors for Biological Thiols." In Comprehensive Supramolecular Chemistry II; Atwood, J. L., Ed.; Oxford: Elsevier: 2017; Vol. 8, p 435-445.

  26. Yin, C.-X.; Xiong, K.-M.; Huo, F.-J.; Salamanca, J. C.; Strongin, R. M. "Fluorescent Probes with Multiple Binding Sites to Distinguish Cys, Hcy and GSH," Angew. Chem., Int. Ed., 56, 13188-13198,(2017). doi:10.1002/anie.201704084

  27. Wang, L.; Barth, C. W.; Sibrian-Vazquez, M.; Escobedo, J. O.; Lowry, M.; Muschler, J.; Li, H.; Gibbs, S. L.; Strongin, R. M. "Far-red and near-infrared seminaphthofluorophores for targeted pancreatic cancer imaging," ACS Omega, 2, 154-163, (2017). doi:10.1021/acsomega.6b00403

  28. Pankow, J. F.; Kim, K.; McWhirter, K. J.; Luo, W.; Escobedo, J. O.; Strongin, R. M.; Duell, A. K.; Peyton, D. H. "Benzene formation in electronic cigarettes," PLoS ONE, 12, e0173055, (2017). doi:10.1371/journal.pone.0173055

  29. Jensen, R. P.; Strongin, R. M.; Peyton, D. H. "Solvent Chemistry in the Electronic Cigarette Reaction Vessel," Sci. Rep., 7, 42549, (2017). doi:10.1038/srep42549

  30. Yue, Y.; Huo, F.; Li, X.; Wen, Y.; Yi, T.; Salamanca, J.; Escobedo, J. O.; Strongin, R. M.; Yin, C. "pH-Dependent fluorescent probe that can be tuned for cysteine or homocysteine," Org. Lett., 19, 82-85, (2017). doi: 10.1021/acs.orglett.6b03357

  31. Li, N.; Wang, Q.; Sibrian-Vazquez, M.; Klipp, R. C.; Reynolds, J. O.; Word, T. A.; Scott, L., Jr.; Salama, G.; Strongin, R. M.; Abramson, J. J.; Wehrens, X. H. T. "Treatment of catecholaminergic polymorphic ventricular tachycardia in mice using novel RyR2 - modifying drugs," Int. J. Cardiol., 668-673, (2016). doi:10.1016/j.ijcard.2016.10.078

  32. Chu, Y.-H.; Sibrian-Vazquez, M.; Escobedo, J. O.; Phillips, A. R.; Dickey, D. T.; Wang, Q.; Ralle, M.; Steyger, P. S.; Strongin, R. M. "Systemic delivery and biodistribution of cisplatin in vivo," Mol. Pharm., 13, 2677-2682, (2016). doi:10.1021/acs.molpharmaceut.6b00240

  33. Yue, Y.; Huo, F.-J.; Yin, C.; Escobedo, J. O.; Strongin, R. M. "Recent progress in chromogenic and fluorogenic chemosensors for hypochlorous acid," Analyst, 141, 1859-1873, (2016). doi:10.1039/C6AN00158K

  34. Barve, A.; Lowry, M.; Escobedo, J. O.; Thainashmuthu, J.; Strongin, R. M. "Fluorescein tri-aldehyde promotes the selective detection of homocysteine," J. Fluoresc., 26, 731-737, (2016). doi:10.1007/s10895-015-1762-3

  35. Chu, Y.-H.; Escobedo, J. O.; Jiang, M.; Steyger, P. S.; Strongin, R. M. "Rhodamine analogues for molecular ruler applications," Dyes Pigm., 126, 46-53, (2015). doi:10.1016/j.dyepig.2015.11.015

  36. Wang, J.; Sibrian-Vazquez, M.; Escobedo, J. O.; Wang, L.; Chu, Y.-H.; Moore, R.; Strongin, R. M. "Templated polymers enable selective capture and release of lysophospatidic acid in human plasma via optimization of non-covalent binding to functional monomers," Analyst, 140, 7572-7577, (2015). doi: 10.1039/C5AN01597A

  37. Hakuna L.; Doughan B.; Escobedo J. O.; Strongin R. "A simple assay for glutathione in whole blood," Analyst, 140, 3339-3342, (2015). doi: 10.1039/C5AN00345H

  38. Wang, L.; Sibrian-Vazquez, M.; Escobedo, J. O.; Wang, J.; Moore, R.; Strongin, R. "Spiroguanidine rhodamines as fluorogenic probes for lysophosphatidic acid," Chem. Commun., 51, 1697-1700, (2014). doi:10.1039/C4CC08818B

  39. Barve, A.; Lowry, M.; Escobedo, J. O.; Huynh, K.; Hakuna, L.; Strongin, R. "Differences in heterocycle basicity distinguish homocysteine from cysteine using aldehyde-bearing fluorophores," Chem. Commun., 50, 8219-8222, (2014). doi:10.1039/C4CC03527E

  40. Yang, X.; Huang, Q.; Zhong, Y.; Li, Z.; Li, H.; Lowry, M.; Escobedo, J. O.; Strongin, R. M. "A dual emission fluorescent probe enables simultaneous detection of glutathione and cysteine/homocysteine," Chem. Sci., 5, 2177-2183, (2014). doi:10.1039/C4SC00308J

  41. Hakuna, L.; Escobedo, J. O.; Lowry, M.; Barve, A.; McCallum, N.; Strongin, R. M. "A photochemical method for determining plasma homocysteine with limited sample processing," Chem. Commun., 50, 3071-3073, (2014). doi:10.1039/C4CC00432A

  42. Wang, J.; Sibrian-Vazquez, M.; Escobedo, J. O.; Lowry, M.; Wang, L.; Chu, Y.-H.; Moore, R. G.; Strongin, R. M. "Simple enrichment and analysis of plasma lysophosphatidic acids," Analyst, 138, 6852-6859 (2013). doi:10.1039/C3AN01168B

  43. Karasawa, T.; Sibrian-Vazquez, M.; Strongin, R. M.; Steyger, P. S. "Identification of cisplatin-binding proteins using agarose conjugates of platinum compounds," PLoS ONE, 8, e66220 (2013). doi:10.1371/journal.pone.0066220

  44. Uribe, P. M.; Mueller, M. A; Gleichman, J. S; Kramer, M. D; Wang, Q.; Sibrian-Vazquez, M.; Strongin, R. M.; Steyger, P. S.; Cotanche, D. A.; Matsui, J. I. "Dimethyl sulfoxide (DMSO) exacerbates cisplatin-induced sensory hair cell death in zebrafish (Danio rerio)," PLoS ONE, 8, e55359 (2013). doi:10.1371/journal.pone.0055359

  45. Sibrian-Vazquez, M.; Escobedo, J. O.; Lowry, M. A.; Fronczek, F. R.; Strongin, R. M. "Field effects induce bathochromic shifts in xanthene dyes," J. Am. Chem. Soc., 134, 10502-10508 (2012). doi:10.1021/ja302445w.

  46. Guo, Y.; Yang, X.; Hakuna, L.; Barve, A.; Escobedo, J. O.; Lowry, M.; Strongin, R. M. "A fast response highly selective probe for the detection of glutathione in human blood plasma," Sensors, 12, 5940-5950 (2012). doi:10.3390/s120505940.

  47. Sibrian-Vazquez, M.; Escobedo, J. O.; Lowry, M.; Strongin, R. M. "Progress toward red and near-infrared (NIR) emitting saccharide sensors," Pure Appl. Chem., 84, 2443-2456 (2012). doi:10.1351/PAC-CON-11-11-06.

  48. Yang, X.; Guo, Y.; Strongin, R. M. "A seminaphthofluorescein-based fluorescent chemodosimeter for the highly selective detection of cysteine," Org. Biomol. Chem, 10, 2739-2741 (2012).

  49. Ye, Y.; Yaeger, D.; Owen, L. J.; Escobedo, J. O.; Wang, J.; Singer, J. D.; Strongin, R. M.; Abramson, J. J. "Designing calcium release channel inhibitors with enhanced electron donor properties: stabilizing the closed state of ryanodine receptor type 1," Mol. Pharmacol., 81, 53-62 (2012).

  50. Escobedo, J. O.; Chu, Y.-H.; Wang, Q.; Steyger, P. S.; Strongin, R. M."Live cell imaging of a fluorescent gentamicin conjugate," Nat. Prod. Commun., 7, 317-320 (2012).

  51. Yang, X.; Guo, Y.; Strongin, R. M. "Conjugate addition/cyclization sequence enables selective and simultaneous fluorescence detection of cysteine and homocysteine," Angew. Chem., Int. Ed., 50, 10690-10693 (2011).

  52. Lim, S.; Lowry, M.; Strongin, R. M. "Progress towards simple and direct detection of adenylosuccinate lyase deficiency in human urine," Aust. J. Chem., 64, 1470-1473 (2011).

  53. Lim, S.; Escobedo, J. O.; Lowry; Strongin, R. M. "Detecting specific saccharides via a single indicator," Chem. Commun., 47 (29), 8295 - 8297 (2011).

  54. Lim, S.; Escobedo, J. O.; Lowry, M.; Xu, X.; Strongin, R. "Selective fluorescence detection of cysteine and N-terminal cysteine peptide residues," Chem. Commun., 46, 5707-5709 (2010).

  55. Escobedo, J. O.; Rusin, O.; Lim, S.; Strongin, R. M.; "NIR dyes for bioimaging applications." Curr. Opin. Chem. Biol., 14, 64-70 (2010).

  56. Sibrian-Vazquez, M.; Escobedo, J. O.; Lim, S.; Samoei, G. K.; Strongin, R. M. "Homocystamides promote free-radical and oxidative damage to proteins," Proc. Natl. Acad. Sci. USA, 107, 551-554, (2010).

  57. Wang, D.; Crowe, W. E.; Strongin, R. M.; Sibrian-Vazquez, M. "Exploring the pH dependence of viologen reduction by alpha-carbon radicals derived from Hcy and Cys," Chem. Commun. 14, 1876-1878 (2009).

  58. Lange, T. S.; McCourt, C.; Singh, R. K.; Kim, K. K.; Singh, A. P.; Luisi, B. S.; Alptürk, O.; Strongin, R. M.; Brard, L "Apoptotic and chemotherapeutic properties of iron(III)-salophene in an ovarian cancer animal model," Drug Design, Development and Therapy, 3, 17-26 (2009).

  59. Sibrian-Vazquez, M.; Strongin, R. M. "Optimizing the Synthesis and red-green-blue emission of a simple organic dye," Supramol. Chem. 21, 107-110 (2009).

  60. Gates, A. T.; Fakayode, S. O.; Lowry, M.: Ganea, G. M.; Murugeshu, A.; Robinson, J. W.; Strongin, R. M.; Warner, I. M. "Gold nanoparticle sensor for homocysteine thiolactone-induced protein Modification," Langmuir, 24,  4107-4113 (2008).

  61. Richard, G.; Marwani, H.; Jiang, S.; Fakayode, S.; Lowry, M.; Strongin, R. M.; Warner, I. M. "Chiral Recognition of amino acids by use of a fluorescent resorcinarene" Appl. Spectrosc., 62, 476-480 (2008).

  62. Williams, A. A.; Fakayode, S. O.; Alpturk, O.; Jones, C. M.; Lowry, M.; Strongin, R. M.; Warner, I. M.  "Determination of enantiomeric compositions of analytes using novel fluorescent chiral molecular micelles and steady state fluorescence measurements," J. Fluoresc., 18, 285-296 (2008).

  63. Bwambok, D. K.; Marwani, H. M.; Fernand, V. E.; Fakayode, S. O.; Lowry, M.; Negulescu, I.; Strongin, R. M.; Warner, I. M.  "Synthesis and characterization of novel chiral ionic liquids and investigation of their enantiomeric recognition properties," Chirality, 20, 151-158 (2008).

  64. Lange, T. S.; Kim, K. K.; Singh, R. K.; Strongin, R. M.; McCourt, C. K.; Brard, L. "Iron(III)-salophene: an organometallic compound with selective cytotoxic and anti-proliferative properties in platinum-resistant ovarian cancer cells," PLoS One,3, e2303, (2008).

  65. Yang, Y.; Lowry, M.; Xu, X.; Escobedo, J. O.; Sibrian-Vazquez, M.; Wong, L.; Schowalter, C. M.; Jensen, T. J.; Fronczek, F. R.; Warner, I. M.; Strongin, R. M.; "Seminaphthofluorones are a family of water-soluble, low molecular weight, NIR-emitting fluorophores," Proc. Natl. Acad. Sci. USA, 105, 8829-8834 (2008).

  66. Gates, A. T.; Lowry, M.; Fletcher, K. A.; Merugeshu, A.; Rusin, O.; Robinson, J. W.; Strongin, R. M.; Warner, I. M. "Capillary electrophoretic screening for the inhibition of homocysteine thiolactone-induced protein oligomerization," Anal. Chem., 79, 8249-8256 (2007).

  67. Schneider, H.-J.; Kato, K.; Strongin, R. M. "Chemomechanical polymers as sensors and actuators for biological and medicinal applications," Sensors, 7, 1578-1611 (2007).

  68. Fletcher, K. A.; Fakayode, S. O.; Lowry, M.; Tucker, S. A.; Neal, S. L.; Kimaru, I. W.; McCarroll, M. E.; Patonay, G.; Oldham, P. B.; Rusin, O.; Strongin, R. M.; Warner, I. M. "Molecular fluorescence, phosphorescence and chemiluminescence spectrometry," Anal. Chem. 78, 4047-4068 (2006).

  69.  Pacsial-Ong, E.; McCarley, R. L.; Wang, W.; Strongin, R. M. "Electrochemical Detection of glutathione using redox indicators," Anal. Chem. 78, 7577-7581 (2006).

  70.  Jiang, S.; Escobedo, J. O.; Kim, K. K.; Alpturk, O.; Samoei, G.; Fakayode, S. O.; Rusin, O.; Warner, I. M.;  Strongin, R. M. "Stereochemical and regiochemical trends in the selective spectrophotometric  detection of saccharides," J. Am. Chem. Soc., 128, 12221-12228 (2006).

  71.  Alpt?rk, O.; Rusin, O.; Fakayode, S. O.; Wang, W.; Escobedo, J. O.; Warner, I. M.; Krl, V.; Strongin, R. M. "Lanthanide complexes as fluorescent indicators for neutral sugars and small molecule cancer biomarkers," Proc. Natl. Acad. Sci. USA, 103, 9756-9760 (2006).

  72. Samoei, G.; Wang, W.; Xu, X.; Escobedo, J. O.; Schneider, H.-J.; Strongin, R. M. "A chemomechanical polymer that functions in blood plasma with high glucose selectivity," Angew. Chem., Int. Ed. Engl., 45, 5319-5322 (2006).

  73. Yang, Y.; Lowry, M.; Schowalter, C. M.; Fakayode, S. O.; Escobedo, J. O.; Xu, X.; Zhang, H.; Jensen, T. J.; Fronczek, F. R.; Warner, I. M.; Strongin, R. M. "An organic white light-emitting fluorophore," J. Am. Chem. Soc., 128, 14081-14092 (2006).

  74. Escobedo, J. O.; Wang, W.; Strongin, R. M.  "Using a commercially available reagent for the selective detection of homocysteine in plasma," Nat. Protoc., 1, 2759-2762 (2006).

 

 

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