Keith D. Garlid MD PhD - Portland State University

Publications

Articles

A. D. Costa, K. D. Garlid, I. C. West, T. M. Lincoln, J. M. Downey, M. V. Cohen, S. D. (2005) Protein kinase G transmits the cardioprotective signal from cytosol to mitochondria. Circ Res. 2005 Aug 19; 97(4):329-36. (PDF)
K. D. Garlid, A. D. Costa, M. V. Cohen, J. M. Downey, S. D. Critz. (2004) Cyclic GMP and PKG activate mito K(ATP) channels in isolated mitochondria. Cardiovasc J S Afr. 2004 Jul; 15.
G. D. Mironova, A. E. Negoda, B. S. Marinov, P. Paucek, A. D. T. Costa, S. M. Grigoriev, Y. Y. Skarga and K. D. Garlid. (2004) Functional distinctions between the mitochondrial ATP-dependent K + channel (mitoK ATP) and its inward rectifier subunit (mitoKIR). J Biol Chem. 279. 32562-8. (PDF)
M. Jaburek, S. Miyamoto, P. Di Mascio, K. D. Garlid and P. Jezek. (2004) Hydroperoxy fatty acid cycling mediated by mitochondrial uncoupling protein UCP2. J Biol Chem. 8. 8. (PDF)
K. D. Garlid, A. D. Costa, M. V. Cohen, J. M. Downey and S. D. Critz. (2004) Cyclic GMP and PKG activate mito K(ATP) channels in isolated mitochondria. Cardiovasc J S Afr. 15. S5.
Garlid, K. D. (2004) Chemiosmotic Theory. Enclopedia of Biol Chem, Elsevier, Amsterdam pp 405-412. (PDF)
Dos Santos, P., Laclau, M. N., Boudina, S. and Garlid, K. D. (2004) Alterations of the bioenergetics systems of the cell in acute and chronic myocardial ischemia. Mol Cell Biochem 256/257, 157-166.
M. Jaburek and K. D. Garlid (2003) Reconstitution of Recombinant Uncoupling Proteins - UCP1, 2, and 3 Have Similar Affinities for ATP and Are Unaffected by Coenzyme Q10. J. Biol. Chem. 278, 25825-31.
O. Oldenburg, X-M. Yang, K. D. Garlid, M. V. Cohen, G. J. Grover, and J. M. Downey (2003) P1075 Opens Mitochondrial KATP Channels and Generates Reactive Oxygen Species Resulting in Cardioprotection of Rabbit Hearts. J. Mol. Cell. Cardiol. Submitted and in review.
K. D. Garlid, and P. Paucek (2003) Mitochondrial potassium transport: the K+ cycle. Biochim Biophys Acta 23-41. (PDF)
K. D. Garlid, P. Dos Santos, Z. Xie, and P. Paucek (2003) Mitochondrial potassium transport: the role of the mitochondrial ATP-sensitive K+channel in cardiac function and cardioprotection. Biochim Biophys Acta 1-21. (PDF)
J. Tian, J. Liu, J. I. Shapiro, K. D. Garlid, and Z. Xie (2002) Involvement of Mitogen-activated Protein Kinases and Reactive Oxygen Species in the Inotropic Action of Ouabain on Cardiac Myocytes. A Potential Role for Mitochondrial KATP Channels. Mol Cell Biochem 242, 181-187.
M. Krenz, O. Oldenburg, H. Wimpee, M. V. Cohen, K. D. Garlid, S. D. Critz, J. M. Downey, and J. N. Benoit (2002) Opening of ATP-sensitive potassium channels causes generation of free radicals in vascular smooth muscle cells. Basic Res. Cardiol. 97, 365-373. (PDF)
P. Dos Santos, A. J. Kowaltowski, M. N. Laclau, S. Seetharaman, P. Paucek, S. Boudina, J.-B. Thambo, L. Tariosse, and K. D. Garlid (2002) Mechanisms by which opening the mitochondrial ATP-sensitive potassium channel protects the ischemic heart. Am. J. Physiol. Heart Circ. Physiol. 283, H284-95. (PDF)
M. Laclau, P. Dos Santos, L. Tariosse, S. Boudina, and K. D. Garlid (2002) Opening of heart mitochondrial ATP-sensitive potassium channel is mandatory to respond to calcium-induced positive inotropic stress. J Mol Cell Cardiol 34, A37, 2002.
P. Dos Santos, A. J. Kowaltowski, M. N. Laclau, S. Seetharaman, P. Paucek, S. Boudina, J. B. Thambo, L. Tariosse, and K. D. Garlid (2002) Mechanism by which opening the mitochondrial ATP-sensitive potassium channel protects the ischemic heart. J Mol Cell Cardiol 34, A21, 2002.
Tian, J., Liu, J., Garlid, K.D. and Xie, Z. (2002) Signal-transducing function of Na/K-ATPase is involved in regulation of contractility by ouabain in cardiac myocytes. Biophys. J. In press.
P. Paucek, E. Crucerescu, and K. D. Garlid (2002) Purification of mitoKATP subunits for amino acid sequencing. Biophys. J. 82, 109A.
P. Paucek, L. Dolgacova, and K. D. Garlid (2002) Purification and reconstitution of KATP channel (pmitoKATP) of plant mitochondria. Biophys. J. 82, 109A.
P. Paucek, M. Jaburek, P. Jezek, J. Jezek, and K. D. Garlid (2002) Purification of brain mitochondrial Na+/Ca2+ antiporter. Biophys. J. 82, 109A.
S. Seetharaman, V. Zinchenko P. Paucek, and K. D. Garlid (2002) Volume activation of mitochondrial electron transport. Biophys. J. 82, 109A.
J. Tian, J. Liu, J. I. Shapiro, K. D. Garlid, and Z. Xie (2002) Involvement of Mitogen-activated Protein Kinases and Reactive Oxygen Species in the Inotropic Action of Ouabain on Cardiac Myocytes. A Potential Role for Mitochondrial KATP Channels. Mol Cell Biochem 242, 181-187. (Abstract)
M. Krenz, O. Oldenburg, H. Wimpee, M. V. Cohen, K. D. Garlid, S. D. Critz, J. M. Downey, and J. N. Benoit (2002) Opening of ATP-sensitive potassium channels causes generation of free radicals in vascular smooth muscle cells. Basic Res. Cardiol. 97, 365-375. (Abstract)
P. Dos Santos, A. J. Kowaltowski, M. N. Laclau, S. Seetharaman, P. Paucek, S. Boudina, J.-B. Thambo, L. Tariosse, and K. D. Garlid (2002) Mechanisms by which opening the mitochondrial ATP-sensitive potassium channel protects the ischemic heart. Am. J. Physiol. Heart Circ. Physiol. 283, H284-95. (Abstract)
P. Paucek, R. Bajgar, S. Seetharaman, G. Grover, M. A. Smith, P. G. Sleph, and K. D. Garlid (2001) The cardioprotective P-1075 targets mitoKATP in heart mitochondria. J. Mol. Cell. Cardiol. 33, A91.
A. J. Kowaltowski, S. Seetharaman, P. Paucek, and K. D. Garlid (2001) The mitochondrial ATP-sensitive K+ channel regulated oxidative phosphorylation and ATP hydrolysis. Biophys. J. 80, 498a.
K. D. Garlid, and P. Paucek (2001) The mitochondrial potassium cycle. IUBMB Life 52, 153-158. (Abstract) (PDF)
R. Bajgar, S. Seetharaman, A. J. Kowaltowski, K. D. Garlid, and P. Paucek (2001) Identification and properties of a novel intracellular (mitochondrial) ATP-sensitive potassium channel in brain. J. Biol. Chem. 276, 33369-33374. (PDF)
M. Jaburek, M. Vaoecha, P. Jezek, and K. D. Garlid (2001) Alkylsulfonates as probes of uncoupling protein transport mechanism. Ion pair transport demonstrates that direct H+ translocation by UCP1 is not necessary for uncoupling. J. Biol. Chem. 276, 31897-31905. (PDF)
G. J. Grover, A. J. D'Alonzo, K. D. Garlid, R. Bajgar, N. J. Lodge, P. G. Sleph, R. B. Darbenzio, T. A. Hess, M. A. Smith, P. Paucek, and K. S. Atwal (2001) Pharmacologic characterization of BMS-191095, a mitochondrial KATP opener with no peripheral vasodilator or cardiac action potential shortening activity. J. Pharmacol. Exp. Ther. 297, 1184-1192. (Abstract) (PDF)
M. N. Laclau, S. Boudina, J. B. Thambo, L. Tariosse, G. Gouverneur, S. Bonoron-Adele, V. A. Saks, K. D. Garlid, and P. Dos Santos (2001) Cardioprotection by ischemic preconditioning preserves mitochondrial function and functional coupling between adenine nucleotide translocase and creatine kinase. J. Mol. Cell. Cardiol. 33, 947-956. (Abstract) (PDF)
A. J. Kowaltowski, S. Seetharaman, P. Paucek, and K. D. Garlid (2000) Bioenergetic consequences of opening the ATP-sensitive K+ channel of heart mitochondria. Am. J. Physiol. Heart Circ. Physiol. 280, H649-H657.(Abstract) (PDF)
A. Banerjee, B. J. Pomeranz, T. Robinson, T. D. Morrell, A. H. Harken, K. D. Garlid, and C. B. Cairns (2000) Mitochondrial KATP channel opening confers protection against ischemia-reperfusion injury in human myocardium by enhanced oxygen consumption during reperfusion. 73rd American Heart Association Scientific Sessions
P. Paucek, K. D. Garlid, A. J. D'Alonzo, P. G. Sleph, R. B. Darbenzio, T. A. Hess, K. S. Atwal, and G. J. Grover (2000) BMS-191095, a selective mitochondrial KATP opener. J. Mol. Cell. Cardiol. 32, A53.
K. D. Garlid, A. J. Kowaltowski, S. Seetharaman, and P. Paucek (2000) The mitochondrial KATP channelCits role in cardiac function and in prevention of ischemia-reperfusion injury. Eur. J. Med. Res. 5, 17.
P. Paucek, R. Bajgar, A. J. Kowaltowski, S. Seetharaman, and K. D. Garlid (2000) The mitochondrial ATP-sensitive K+ channel (mitoKATP). EBEC Short Rep. 11, 96.
R. Bajgar, P. Paucek, G. Fiskum, and K. D. Garlid (2000) Identification and functional reconstitution of brain mitochondrial mitoKATP. Biophys. J. 78, 139A. (PDF)
K. D. Garlid (2000) Opening mitochondrial KATP in the heartCwhat happens, and what does not happen. Basic. Res. Cardiol. 95, 275-279. (Abstract) (PDF)
K. D. Garlid, M. Jaburek, P. Jezek, and M. Varecha (2000) How do uncoupling proteins uncouple? Biochim. Biophys. Acta 1459, 383-389. (Abstract) (PDF)
P. E. Puddu, K. D. Garlid, F. Monti, K. Iwashiro, S. Picard, A. A. Dawodu, A. Criniti, G. Ruvulo, and P. P. Campa (2000) Bimakalim: a promising KATP channel activating agent. Cardiovasc. Drug. Rev. 18, 25-46.
G. J. Grover and K. D. Garlid (2000) ATP-sensitive potassium channels: a review of their cardioprotective pharmacology. J. Mol. Cell. Cardiol. 32, 677-695. (Abstract) (PDF)
K. D. Garlid (2000) The state of water in biological systems. Int. Rev. Cytol. 192, 281-302. (Abstract) (PDF)
P. Paucek, R. Bajgar, and K. D.Garlid (1999) Regulatory Sites of MitoKATP are on MitoSUR. Biophys. J. 76, A328.
B. J. Pomerantz, J. C. Cleveland, Jr., K. D. Garlid, A. Banerjee, and A. H. Harken (1999) Adenosine-mediated cardiac preconditioning extends beyond opening of the mitochondrial KATP channel in human myocardium. Surg. Forum 50, 94-96.
M. Jaburek, M. Varecha, R. E. Gimeno, M. Dembski, P. Jezek, M. Zhang, P. Burn, L. A. Tartaglia, and K. D. Garlid (1999) Transport function and regulation of mitochondrial uncoupling proteins 2 and 3. J. Biol. Chem. 274, 26003-26007. (Abstract) (PDF)
P. Jezek, M. Zackova, Z. Rehakova, M. Ruzicka, J. Borecky, E. Skobisova, J. Brucknerova, K. D. Garlid, R. E. Gimeno, and L. A. Targaglia (1999) Existence of uncoupling protein-2 antigen in isolated mitochondria from various tissues. FEBS Lett. 455, 79-82. (Abstract) (PDF)
P. Jezek and K. D. Garlid (1998) Mammalian mitochondrial uncoupling proteins. Int. J. Biochem. Cell Biol. 30, 1163-1168. Review. (Abstract) (PDF)
K. D. Garlid, M. Jaburek, and P. Jezek (1998) The mechanism of proton transport mediated by mitochondrial uncoupling proteins. FEBS Lett. 438, 10-14. (Abstract) (PDF)
P. Jezek, H. Engstova, M. Zackova, A. E. Vercesi, A. D. T. Costa, P. Arruda, and K. D. Garlid (1998) Fatty acid cycling mechanism and mitochondrial uncoupling proteins. Biochim. Biophys. Acta 1365, 319-327. (Abstract)
M. Jaburek, V. Yarov-Yarovoy, P. Paucek, and K. D. Garlid (1998) State-dependent inhibition of the mitochondrial KATP channel by glyburide and 5-hydroxydecanoate. J. Biol. Chem. 273, 13578-13582. (Abstract) (PDF)
K. D. Garlid, P. Paucek, V. Yarov-Yarovoy, H. N. Murray, R. B. Darbenzio, A. J. D'Alonzo, N. J. Lodge, M. A. Smith, and G. J. Grover (1997) Cardioprotective effect of diazoxide and its interaction with mitochondrial ATP-sensitive K+ channels. Possible mechanism of cardioprotection. Circ. Res. 81, 1072-1082. (Abstract)
M. Modriansky, D. L. Murdza-Inglis, H. V. Patel, K. B. Freeman, and K. D. Garlid (1997) Identification by site-directed mutagenesis of three arginines in uncoupling protein that are essential for nucleotide binding and inhibition. J. Biol. Chem. 272, 24759-24762. (Abstract) (PDF)
V. Yarov-Yarovoy, P. Paucek, M. Jaburek, and K. D. Garlid (1997) The nucleotide regulatory sites on the mitochondrial KATP channel face the cytosol. Biochim. Biophys. Acta 1321, 128-136. (Abstract) (PDF)
P. Jezek, M. Modriansky, and K. D. Garlid (1997) A structure-function study of fatty acid interaction with mitochondrial uncoupling protein. FEBS Lett. 408, 166-170. (Abstract) (PDF)
P. Jezek, M. Modriansky, and K. D. Garlid (1997) Inactive fatty acids are unable to flip-flop across the lipid bilayer. FEBS Lett. 408, 161-165. (Abstract) (PDF)
P. Paucek, V. Yarov-Yarovoy, X. Sun, and K. D. Garlid (1996) Inhibition of the mitochondrial KATP channel by long-chain acyl-CoA esters and activation by guanine nucleotides. J. Biol. Chem. 271, 32084-32088. (Abstract) (PDF)
K. D. Garlid (1996) Cation transport in mitochondria B the potassium cycle. Biochim. Biophys. Acta 123-126. (Abstract) (PDF)
K. D. Garlid, P. Paucek, V. Yarov-Yarovoy, X. Sun, and P. A. Schindler (1996) The mitochondrial KATP channel as a receptor for potassium channel openers. J. Biol. Chem. 271, 8796-8799. (Abstract) (PDF)
P. Jezek, J. Hanus, C. Semrad, and K. D. Garlid (1996) Photoactivated azido fatty acid irreversibly inhibits anion and proton transport through the mitochondrial uncoupling protein. J. Biol. Chem. 271, 6199-6205. (Abstract) (PDF)
K. D. Garlid, D. E. Orosz, M. Modriansky, S. Vassanelli, and P. Jezek (1996) On the mechanism of fatty acid-induced proton transport by mitochondrial uncoupling protein. J. Biol. Chem. 271, 2615-2620. (Abstract) (PDF)
P. Jezek, M. Bauer, P. D. Vogel, K. D. Garlid, and W. E. Trommer (1995) Fatty acid binding to the mitochondrial uncoupling protein. Bull. Magn. Reson. 17, 126-129.
K. D. Garlid, X. Sun, P. Paucek, and G. Woldegiorgis (1995) Mitochondrial cation transport systems. Methods Enzymol. 260, 331-348.
K. D. Garlid (1994) Mitochondrial cation transport: A progress report. J. Bioenerg. Biomembr. 26, 537-542. (Abstract)
P. Jezek, D. E. Orosz, M. Modriansky, and K. D. Garlid (1994) Transport of anions and protons by the mitochondrial uncoupling protein and its regulation by nucleotides and fatty acids. A new look at old hypotheses. J. Biol. Chem. 269, 26184-26190. (Abstract) (PDF)