Chemistry 332 - Winter 1997

Homework - Chapter 17

McMurry, pp 527-529:
Problems 17.10-21,24-29


Examine each of the 8 steps in the citric acid cycle shown on page 521.

For each step, identify whether the reaction involved includes one or more of the following reaction types: oxidation, reduction, addition, elimination, substitution.

For each step, identify the functional group(s) that undergo change in the reaction.

For oxidation/reduction reactions, indicate what gets oxidized and what gets reduced.

Note that some steps are actually a combination of more than one reaction, and it would be most helpful to describe each one separately.

Example: Step 1 (oxaloacetate to citrate) is an addition - specifically a nucleophilic addition of the alpha position of acetyl coA to the ketone group of oxaloacetate.