Chemistry 332 - Spring 1996
Elements of Organic Chemistry II
Homework, Chapter 17 - Metabolism
McMurry, pp 527-529:
Problems 17.10-21,24-29
Examine each of the 8 steps in the citric acid cycle shown on page 521.
For each step, identify whether the reaction involved includes one or more
of the following reaction types: oxidation, reduction, addition, elimination,
substitution.
For each step, identify the functional group(s) that undergo change in the
reaction.
For oxidation/reduction reactions, indicate what gets oxidized and what
gets reduced.
Note that some steps are actually a combination of more than one reaction,
and it would be most helpful to describe each one separately.
Example: Step 1 (oxaloacetate to citrate) is an addition - specifically
a nucleophilic addition of the alpha position of acetyl coA to the ketone
group of oxaloacetate.