Organic Chemistry III |
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Professor Carl C. Wamser |
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Chem 336 - Spring 2008 |
Chapter 28 Homework |
Carey, pages 1238 - 1241 :
Problems 28.14 - 24
1. Sickle cell anemia is a genetic defect in the structure of hemoglobin, in which just one amino acid is altered. One glutamic acid is replaced by a valine. Describe why this change could be so serious for the protein tertiary structure.
Suggest a possible code in the DNA that might have been altered in order to read Val instead of Glu.
2. Some codons can be deduced from simple homopolynucleic acids, e.g., poly-A. Explain.
Identify the four amino acid codes that can be deduced this way.