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Organic
Chemistry III
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Professor
Carl C. Wamser
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Chapter
21 Skills
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Ester Enolates
Knowledge - Level 1
know the terminology:
Claisen condensation
Dieckmann condensation
acetoacetic ester, malonic ester
barbiturates
alkylation, acylation
LDA
Concepts - Level 2
recognize the acidity of beta-dicarbonyl compounds and their enolates
as nucleophiles
Applications - Level 3
predict products of Claisen condensations, including cases of intramolecular
or mixed condensations
predict products from malonic ester or acetoacetic ester syntheses
Analytical Skills - Level 4
write mechanisms for base-catalyzed Claisen condensations
Synthetic Skills - Level 5
create a synthetic sequence to prepare a given target molecule
especially using Claisen condensations or the malonic or acetoacetic ester
syntheses
