Organic Chemistry III
	Professor Carl C. Wamser
	Chapter 18 Skills	Chem 336 - Spring 2005

Enols & Enolates

Knowledge - Level 1

Terminology:

aldol condensation, mixed aldol
Michael reaction, conjugate addition
Robinson annulation

Concepts - Level 2

recognize the nucleophilicity of carbonyl alpha-anions

recognize the special reactivity of conjugated enones towards nucleophiles
(conjugate or Michael addition)

Applications - Level 3

predict products of aldol ractions including cases of intramolecular or mixed reactions

predict products from Michael additions

illustrate or identify the Robinson annulation reaction sequence

Analytical Skills - Level 4

write mechanisms for aldol reactions

write mechanisms for alpha-substitution reactions

write mechanisms for conjugate addition reactions

Synthetic Skills - Level 5

create a synthetic sequence to prepare a given target molecule,
especially using aldol condensation