Chem 336 - Spring 2000
Organic Chemistry III
Dr. Carl C. Wamser

Chapter 28 Puzzler

Nitrite (NO2-) or nitrous acid (HONO) can act as a mutagen, in that it converts C to U .

a) Show how this reaction might occur.
b) Find two cases where a C to U mutation would NOT affect protein synthesis.
c) Identify the case where such a mutation could cause the MOST drastic change.