Chem 336 - Spring 2000
Organic Chemistry III

Dr. Carl C. Wamser


Chapter 28 Homework

Brown & Foote, pages 1132 - 1135 :
Problems 28.8 - 22 , 25 - 36


1. Sickle cell anemia is a genetic defect in the structure of hemoglobin, in which just one amino acid is altered. One glutamic acid is replaced by a valine. Describe why this change could be so serious for the protein tertiary structure. Suggest a possible code in the DNA that might have been altered in order to read Val instead of Glu.

2. Some codons can be deduced from simple homopolynucleic acids, e.g., poly-A.
Explain. Identify the four amino acid codes that can be deduced this way.