Chem 335 - Winter 1999 -
Organic Chemistry II know the terminology:
aldol condensation, crossed aldol, directed aldol
Claisen condensation
kinetic vs. thermodynamic control
enamine
alkylation, acylation
acetoacetic ester, malonic ester
Michael reaction, conjugate addition
Robinson annelation
acetyl Co-A
recognize the reasons for kinetic vs. thermodynamic control of a reaction
recognize the nucleophilicity of carbonyl alpha-anions
recognize the special reactivity of conjugated enones towards
nucleophilicity
(conjugate or Michael addition)
predict products of aldol ractions or Claisen condensations,
including cases of intramolecular or crossed reactions
predict products from enamine alkylations or acylations
predict products from Michael additions
predict products from malonic ester or acetoacetic ester syntheses
illustrate or identify the Robinson annelation reaction sequence
write mechanisms for acid- or base-catalyzed aldol reactions
write mechanisms for base-catalyzed Claisen condensations
create a synthetic sequence to prepare a given target molecule
especially using aldol or Claisen condensations, enamines,
or the malonic or acetoacetic ester syntheses