Organic Chemistry II |
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Professor Carl C. Wamser |
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Chem 335 - Winter 2009 |
Chapter 18 Skills |
Knowledge - Level 1
Terminology:
aldol condensation, mixed aldol
Michael reaction, conjugate addition
Robinson annulation
recognize the nucleophilicity of carbonyl alpha-anions
recognize the special reactivity of conjugated enones towards nucleophiles
(conjugate or Michael addition)
predict products of aldol ractions including cases of intramolecular or mixed reactions
predict products from Michael additions
illustrate or identify the Robinson annulation reaction sequence
write mechanisms for aldol reactions
write mechanisms for alpha-substitution reactions
write mechanisms for conjugate addition reactions
create a synthetic sequence to prepare a given target molecule,
especially using aldol condensation