Chem 336 - Spring 1999 - Organic Chemistry III
Portland State University - Dr. Carl C. Wamser

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Chapter 28 Homework

Brown & Foote, pages 1132 - 1135 :
Problems 28.8 - 22 , 25 - 36

1. Sickle cell anemia is a genetic defect in the structure of hemoglobin, in which just one amino acid is altered. One glutamic acid is replaced by a valine. Describe why this change could be so serious for the protein tertiary structure. Suggest a possible code in the DNA that might have been altered in order to read Val instead of Glu.

2. Some codons can be deduced from simple homopolynucleic acids, e.g., poly-A.
Explain. Identify the four amino acid codes that can be deduced this way.