Chem 336 - Spring 2002
Organic Chemistry III
Dr. Carl C. Wamser
know the terminology:
Claisen condensation
Dieckmann condensation
acetoacetic ester, malonic ester
barbiturates
alkylation, acylation
LDA
recognize the acidity of beta-dicarbonyl compounds and their enolates as nucleophiles
predict products of Claisen condensations, including cases of intramolecular or mixed condensations
predict products from malonic ester or acetoacetic ester syntheses
write mechanisms for base-catalyzed Claisen condensations
create a synthetic sequence to prepare a given target molecule
especially using Claisen condensations or the malonic or acetoacetic
ester syntheses