David H. Peyton, Ph.D.

Professor of Chemistry
Portland State University

eMail:  peytond@pdx.edu


Other Appointments: 



University of California at Santa Barbara


1983 - 1985

Weill Medical College of Cornell University


1985 - 1987

University of California at Davis

Visiting Scholar


Cambridge University

Visiting Professor


Tsukuba University


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Medicinal Chemistry

Biophysical Chemistry

The main research theme in the Peyton research group is the study of the relation of structure to function in biological molecules by application of nuclear magnetic resonance spectroscopy. However, other tools may be used, depending on the nature of a particular problem. These tools include organic synthesis, electronic spectroscopy, and computer modeling/dynamics.

The following is a ‘gallery’ of some of the specific projects that are currently being investigated. Some of these projects are fairly mature, while others are just getting started.

Reversed Chloroquines as Antimalarial Agents

Chloroquine (CQ) is one of the safest and most effective drugs ever developed, but resistance has emerged against it. We have developed a way to modify CQ to circumvent this problem.


Antimalarial drug design:
Xanthones and related

This is being done in collaboration with Michael Riscoe, of the Portland VA Hospital.

Xanthones bind to heme, making them potential agents against parasites causing diseases, including malaria and leishmaniasis.


This is being done in collaboration with Hans Peter Bächinger, of the Portland Shriners Hospital.

After so many years as a textbook case, we still don’t really know the canonical reasons for the stability of collagen, our most abundant protein. We are particularly interested in glycosylated collagens, lacking hydroxyproline.

Nicotine in cigarette smoke

This is being done in collabaration with Jim Pankow, of the Oregon Graduate Institute/OH&SU.

The amount and the protonation state of nicotine in cigarette smoke are key factors in both traditional and ‘reduced harm’ cigarettes. NMR provides a way to assess these quantities.

Selected & Recent Publications:

Synthesis, Structure-Activity Relationship, & Mode-of-Action Studies of Antimalarial Reversed Chloroquine Compounds
Burgess, S.J., Kelly, J.X., Shomloo, S., Wittlin, S., Brun, R., Liebmann, K., & Peyton, D.H. (2010) J. Med. Chem., 53, 6477-6489

Reversal Agent and Linker Variants of Reversed Chloroquines: Activities against Plasmodium falciparum
Andrews, S., Burgess, S.J., Skaalrud, D., Kelly, J.X., & Peyton,  D.H. (2010) J. Med. Chem., 53, 916–919

Effect of the -Gly-3(S)-hydroxyprolyl-4(R)-hydroxyprolyltripeptide unit on the stability of collagen model peptides
Mizuno, K., Peyton, D.H., Hayashi, T., Engel, J., & Bächinger, H.P. (2008) FEBS J., 275, 5830-5840

An Expression System to Screen for Inhibitors of Parasite Glucose Transporters
Landfear, S.M., Feistel, T., Hodson, C.A., & Peyton, D.H. (2008) Mol. Cell. Parasitol., 162, 71-76

Synthesis and heme-binding correlation with antimalarial activity of 3,6-bis-(omega-N,N-diethylaminoamyloxy)-4,5-difluoroxanthone
Dodean, R.A., Kelly, J.X., Peyton, D.H., Gard, G.L., Riscoe, M.K., & Winter, R.W. (2008) Bioorg. Med. Chem. 16, 1174-1183

Tobacco smoke particulate matter chemistry by NMR
Barsanti K.C., Luo W., Isabelle L.M., Pankow J.F., Peyton D.H. (2007) Magn. Reson. Chem. 459, 167-170

A Chloroquine-like Molecule Designed to Reverse Resistance in Plasmodium falciparum
Burgess, S. J.; Selzer, A.; Kelly, J. X.; Smilkstein, M. J.; Riscoe, M. K.; Peyton, D. H. (2006) J. Med. Chem. 49, 5623-5625

The Peptides Acetyl-(Gly-3(S)Hyp-4(R)Hyp)10-NH2 and Acetyl-(Gly-Pro-3(S)Hyp))10-NH2 do not form a Collagen Triple Helix
K. Mizuno, T, Hayashi, D.H. Peyton, & H.P Bächinger (2004) J. Biol. Chem., 279, 282-287

The role of carbohydrate in stabilizing the triple-helix in a model for a deep-sea hydrothermal vent worm collagen
J.G. Bann, H.P. Bächinger, & D.H. Peyton (2003) Biochemistry, 42, 4042-4048

Fraction of Free-Base Nicotine in Fresh Smoke Particular Matter from the Eclipse “Cigarette” by 1H NMR Spectroscopy
J.F. Pankow, K.C Barsanti, & D.H. Peyton (2003) Chem. Res. Toxicol., 16, 23-27

Antileishmanial Drug Development: Exploitation of Parasite Heme Dependency
J.X. Kelly, M.V. Ignatuschenko, R.W. Winter, H.G. Bouwer, D.H. Peyton, D.J. Hinrichs, & M. Riscoe (2003) Mol. Biochem. Parasitol., 126, 43-49

A Circularly Permuted Myoglobin Possesses a Folded Structure and Ligand Binding Similar to Wild-type Protein but with Reduced Thermodynamic Stability
A.L. Fishburn, J.R. Keeffe, A.V. Lissounov, D.H. Peyton, & S.J. Anthony-Cahill (2002) Biochemistry, 41, 13318-13327

The Kinetics of Uptake and Accumulation of 3,6-w-diethylaminoamyloxyxanthone by the Human Malaria parasite Plasmodium falciparum
J.X. Kelly, R.W. Winter, A. Cornea, D.H. Peyton, D.J. Hinrichs, & M. Riscoe (2002) Mol. Biochem. Parasitol., 123,  47-54

Optimization of Xanthones for Antimalarial Activity, the 3,6-w-diethylaminoalkoxyxanthone Series
J.X. Kelly, R. Winter, D.H. Peyton, D.J. Hinrichs, & M.K. Riscoe (2002) Antimicrob.  Agts. Chemo., 46, 144-150

Antileishmanial Drug Development: Exploitation of Parasite Heme Dependency
J.X. Kelly, M.V. Ignatuschchenko, R.W. Winter, H.G. Bouwer, D.H. Peyton, D.J. Hinrichs, & M. Riscoe (2002) Mol. Biochem. Parasitol., 123, 47-54

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