Bi341Home Page for syllabus materials
GeneralComments for introduction
Study hints from former students added to home page
Home made animations.. moviepage.html
Chromosome markers
C-banding.jpgMitoticSpread.JPG from the web
Human idiogram....HumIdiogram.GIF
rob's karyotype reduced.... rob1reduced.JPG
rob's karyotype large ....rob1.JPG
Newman's karyotype... NewmanChroms.GIF
Chromosome Gallery
Delphinium chromosomes by Jill Turnerdel1.JPEG; del10.jpeg; del15.jpeg; del2.JPeg; del3.JPG; del6.jpegPodophyllum chromosomes by Lester Newman
podo1.jpeg;podo10.jpeg;podo11.jpeg;podo12.jpeg;podo13.jpeg;podo13a.JPG;podo14.jpeg;podo15.jpeg;podo16.jpeg;podo2.jpeg;podo3.jpeg;podo4.jpeg;podo5.jpeg;podo6.jpeg;podo7.jpeg;podo8.jpeg;podo9.jpeg;podo9a.JPGHuman chromosomes by Rob
rob1.JPG;rob1reduced.JPG;rob3.JPG;rob4.JPG;rob5.JPG;rob6.JPG
details of mitosis
mitosis diagram modifiedMitosis.GIFmitosis animation moviepage.html
Examples from Vicia faba:
metaphase, anaphase, telophase---vicia2n.GIFmetaphase---vicia4n.GIF
anaphase---vicia6n.GIF
metaphase (colchicine)--- vicia1c.GIF
metaphase (colchicine)--- vicia3c.GIF
details of meiosis
Outline of stages....... MeiosisStages.GIFMeiosis project ...(access to 17 graphics). StageDescriptions.html
Fingers Model for Meiosis
FingersModel.htmlLicorice Model for Meiosis
licoricemodel.htmllicoricemodel.GIFcrossing-over
crossingover.htmlcrossingover1.GIFcrossing over/ strands
FourStrsandDouble.GIFexamples of pachytene
pachytene-12.GIFmodels and reality
modelsandreality.htmldiagram 1.... meiosis1.GIF
diagram 2.... meiosis2.GIF
A simple cartoon of meiosis... moviepage.html
sex chromosomes
DrosophilaKaryotype.GIF
Variation/ continuous and discontinuous... ContinuousDiscont.GIF
Seven Mendelian Characteristics... SevenChars.GIF
terminologySomeTerminology.GIFsegregation
monohybrid1.GIF
independent assortment
dihybrid1a.GIFsummary
segregation; 1segregation.GIFindependent assortment; 2independentAsst.GIF
comparison of both; 3segrandindasst.GIF
Mendelian conclusions... conclusions.GIF
Punnett Square..
Punnett1.GIF; Punnett2.GIFsegregation and independent assortment (table of ratios)
MonoDihybridRatios.giffraction method of working problems for simple and complex problems
FractionMethod2.GIF
Mendel and chromosomesIndependent Asst and chromosomes/1... IndAsstChromosomes.GIFChromosomes undergo ind. asst.....ChromIndAsst.GIF
plus/letter system for genotypes:
PlusLetterSystem.GIFuse of the line movie... TopBottom.gif
Genotype notation.... GenotypeNotation.GIF
Autosomal and X-linked... AutosXlinked.GIF
Morgan and sex-linkage
MorganSimple.GIFThe three crosses... TheThreeCrosses.GIF
..... ThethreeCrosses.GIFThe three crosses with genotypes.... ThreeCrossesgenotypes.GIF
Morgan and chromosome theory; non-disjunction
May apple .....normal anaII... podoNormalAnaII.GInondisjunction anaII ... podoNondisjAnaII.GIF
... PodoNondisjAnaII.jpgnon disjunction
normal disjunction animation...from moviepage.htmlprimary non disjunction animation... moviepage.html
primary non disjunction.Punnett square..... nondisjunctionPunnett.GIF
metaphase-I non disjunction... BiUnivalents.gif
Problems with genotype symbols
chromosomes X and 2.....PlusLetterAllelism.GIFand larger......... PlusLetterAllelism2.GIF
Sex determination in humans and Drosophila....ChromSexDet.GIF
autosomal linkage/x-linkage
Test in Drosophilapage 1........ XautosomalLinkage1.GIFpage 2....... XautosomalLinkage2.GIF
X-chromosome inactivation
Xinact.GIFPhotomicrograph of X-chromatin body...YohkoAndCell.GIF
Relationship X-chroms and X-chrom bodies
ChromsXbodies.GIFCalico cat diagram .... calico.GIF
Chromosomal basis of segregation and independent assortment
segregation ...ChromSegr.GIFindependent assortment... ChromIndAsst.GIF
Problem with the letter "X"
Article by Griffiths and Mayer-Smith ....useofletterx.htm
ABO phenotypes and genotypes ABOtypes.gifABO antigens... ABOantigens.GIF
lethal genes
LethalYellow.GIFComplementation (first analysis)
Complementation1.GIF
Parental and recombinant gametes and progeny
in the F2ParentalRecombF2.gifin the test cross
ParentalRecombTest1.GIFdependent assortment; parental and recombinant progeny
ParentalRecombF2.gifconcept of map distance (by example)
Black body and vestigial wing are recessive mutations ...Recombination page 1... Recombination1.GIF
Test cross allows for prediction of gametes
BlackVestPunnett.GIFTest cross data for black and vestigial
overviewgenotypes
Recombination3a.GIFanalysis...
Recombination3b.GIFwhat is going on?
Recombination page 4... Recombination4.GIFfrom meiosis part of the course
crossingover3.GIFconclusion
BlackVestConcl1.GIFAdd a third gene
cinnabar...blackvestcin1.GIFProblem of cis/trans (coupling and repulsion in text)
CisTrans1.GIFfor a two gene test cross as 50%
similar to analysis in workbook
Recombination1OneCell.GIFUsing the recombination map
Recombination problem from workbook... RecombProblem.GIF
Mapping function
MappingFunction.GIFComplete linkage in male Drosopila melanogaster
CompleteLinkage.GIFcrossing-over and recombination/ Creighton and McClintock
CreightonMcClintock.gifgrandfather method in humans
GrandFatherMethod1.GIFLinkage Summary... LinkageSummary.html
Summary of genetics tests... SomeGeneticsTests.GIF
Work with line system
From the workbook...CutOut.GIFDrosophila map... DrosophilaMap.GIF
TypesMutations.gifgene and chromosomal mutations
mutations.gifforward and back mutations
ForwardBackMuts.GifTradescantia KU-9
KU9-1.GIFClB
ClB cartoon....ClB01.GIFand, by steps:
chromosome structurecentromere locationCentromereLocation.GIFheterochromatin; euchromatin
Some generalities..... Heterochromatin.GIF
kinds of chromosomes examplesKindsOfChromosomes.GIFmitotic chromosomes.... ExampleMitotic.gif
pachytene chromosomes.... ExamplePachytene.gif
polytene chromosomes.... ExamplePolytene.GIF;
Kinds of chromosome mutations... KindsChromMutations.GIF
animations of the 6 structural mutations
Duplication.... deletion.GIFDeletion...... Duplication2.gif
Paracentric inversion..... ParaInversion.gif
Pericentric inversion.... PeriInversion.gif
Reciprocal translocation.... RecipTransloc.gif
Robertsonian translocation.... Robertsonian.gif
within chromosome mutations:
deletion,deletion1.GIF
deletion mappingDeletionMapping.GIFduplication
duplication.GIFLepore and unequal cross over (not in text)
Unequal crossover..... UnequalCrossOver.GIFLepore model .... Lepore.GIF
inversion
paracentricParaInversion1.GIFSimple animation of bridge and fragment... InversionClay.gif
Another simple animation of bridge and fragment... bandf.mov
individual frames of animation...BridgeFragment.GIFCrossover within paracentric inversion
inversion1.GIFpericentric
PeriInversion1.GIF
between chromosome mutations:
translocationmodels for reciprocal translocation.1. TranslocationMode0l.GIF ...2. TranslocationModel02.GIF3. TranslocationModel03.GIF 4. TranslocationModel04.GIF
5. TranslocationModel05.GIF..6. .TranslocationModel06.GIF
7. TranslocationModel07.GIF..8. .TranslocationModel08.GIF
translocation animation... TransAnimation.gif
Robertsonian translocations
model... Robertsonian1.GIFRobertsonian1a.GIFOverview
ChromMutOverview.gifAction of colchicine... colchicine.GIF
Neurospora generalNeurosporaMedia.GIFAnd more on inborn errors of metabolism
Example primary structure, beta globin: .. AminoAcidSeqs.GIF
Protein complexity... PeptideComplexity
colinearity of gene and protein
Idea:colinearity1.GIF
DNA as the genetic materialTransformation1.GIFWatson; Crick model
single nucleotide modelnucleotide.GIFshort double helix
nucleotideModel.gifChargaff data... Chargaff.GIF
II. DNA more than one copyA Functional1. families of coding genesa dispersed gene familiesGlobinGeneEvolution.GIF
b tandem gene families
HistoneGenes.GIF2. non coding functional sequences
telomeres...telomere storythe problem... OneEndTelomere.GIF
and telomerease..
the telomere materials given below must be revised --------
telomere1.GIF;. this series may have been revised. telomere2.GIF..
B No known function
1. centric heterochromatin... CentricHeterochromatin.GIF
Organization of eukaryotic chromosome model
Junk Garbage statement from Science 263:608 1994 JunkGarbage.gifChromosomeOrganization.GIF (as Fig 16-31)
DNA replication; Meselson/Stahl experimentsThree possible modes of replicationModesOfReplication.GIFMeselson-Stahl diagram
SemiConservRepl.GIFchromosome replication; H. Taylor
Explanation.... TaylorModel.GIFsome details of DNA replication
Konberg experiments.... Kornberg.GIF5' to 3' replication
DNArep1.GIFBubbles
Replication bubble.... bubble.GIF
OverviewProtSynOverview.GIFThe gene
Class2GeneAnatomy.GIFexercise.... Why53given2.GIF
beta globin
betaGlobinGene.GIF
Transcription
RNAPolymerases.GIFdirection of transcription.... TranscriptionDir.GIF
Genetic code
the code.... GeneticCode.GIFcharging of tRNA.... WhichtRNA.GIF
Protein synthesis
ProteinSynth1.GIF
Benzerkinds of infectionvirus animation ..... virus.gifone virus, one spot
Benzer1.giflots of viruses, no spot
Benzer3.GIFkinds of spots
BenzerMutantSpot.GIFcomplementation
Consider the two possibilities for two mutations in transrecombination
BenzerRecombination1.gifThe grand table
BenzerAllelism1.GIFBenzer diagram ... BenzerDiagram.GIF
Pizza and Beer exercise
PizzaBeer.GIF
Overview... RecombinantOverview.GIFrestriction enzymes
RestrictionEnzymes.GIFthe idea..From workbook page 40
PlasmidForeign1.GIFplasmids
plasmid1.GIFprobes
probe1.GIFclones/libraries
PhageLibrary.GIFnucleotide sequencing
DNAsequencing.GIFPCR (remove ?)
PCR1.GIFPCR
PCRpage1.GIFDNA techniques and the Wexler story
Pedigree1.GIF
OperonEvolution.GIF
Lactose not present....operon4.GIF
Lactose present....operon5.GIF
Mutation ... repressorminus.GIF
Mutation ... OperatorMutation.GIF
Mutation ...repressorS.GIF
Add complexity. If both glucose and lactose are present, glucose is used first, then the lactose. Via the CAP binding site at the 5' end of the promotor.
CataboliteRepression.htmlComplex genotypes and the operon model
from workbook: operonWorkBook.gifList of steps.....operonWorkbook2.gif
Table of some genotypes... OperonGenotypes.html
A tutorial which may help with the complex genotypes.. OperonHome.html
A model for repressor-operator....OperonModelScience.GIF
imprinting.GIF
