Patents

Mackiewicz (PI)   

Provisional Patent: “Lipid-coated nanoparticles and methods of making and using the same” MACM-01 March 15, 2016.

Licensing:

·         Nanohybrids for field testing photoacoustic imaging, July 1st, 2017

·         Kerafast for commercialization, September 1st, 2017

 

Publications

1.    Virca, C. N.; Winter, H. M.; Goforth, A. M.; Mackiewicz, M. R.; McCormick, T. M., (2017) Photocatalytic water reduction using a polymer coated carbon quantum dot sensitizer and a nickel nanoparticle catalyst. Nanotechnology, 28 (19), 195402.

 

2.    Hamilton, D. J.; Cai, Y.; Kaur, R.; Marquart, G. W.; Mackiewicz, M. R.; Reed, S. M., (2017) Lipid-Coated Gold Nanoparticles as Probes for Membrane Binding. Humana Press: Totowa, NJ, pp 1-16

 

1.    Ho Wu, R.; Nguyen, T. P.; Marquart, G. M.; Miesen, T. J.; Mau, T.; Mackiewicz, M. R., (2014) A facile route to tailoring peptide-stabilized gold nanoparticles using glutathione as a synthon, Molecules 19(5):6754-75.

 

2.    Sinche, F., Ho Wu, R., Gowrishankar, M., Marquart, G. W., Mackiewicz, M. Rampersad, Harper, B. and S. L. Harper. (2014) “The impact of synthesis method and purity on the toxicity of glutathione-coated gold nanoparticles.”  Nanomaterials 4(2), 355-371.

 

3.     Norris, C.; Rencit, P. R.; Mackiewicz, M. R.; S. M. (2010) “A Simple Synthesis of Gold-Core, Silver-Shell Nanoeggs Using Minimal Formaldehyde.”  Chemistry of Materials, 22 (12), 3637–3645.

 

4.    Mackiewicz, M. R.; Hodges, H. L.; Brown, A. L.; Reed. S. M. (2010) “Nanoparticle-Enhanced Assay for Detection of C - reactive Protein with Phosphatidylcholine ligands.”  Journal of Physical Chemistry B, 114 (16), 5556–5562.

 

5.    Situala, Sarita; Mackiewicz, Marilyn Rampersad; Reed. Scott M. (2008) “Gold Nanoparticles Become Stable to Cyanide Etch when Coated with Hybrid Lipid Bilayers.”  Chemical Communications, 3013–3015.

 

6.    Mackiewicz, Marilyn Rampersad; Ayres, Benjamin R.; Reed, Scott M.  (2008) “Reversible, Reagentless Solubility Changes in Phosphatidylcholine-stabilized Gold Nanoparticles.”  Nanotechnology, 19, 115607-115613.

 

7.    Rampersad, Marilyn. V.; Zuidema, Eric; Ernsting, Jan Meine; van Leeuwen, Piet W. N. M.; Darensbourg, Marcetta Y. (2007) “CO and Ethylene Migratory Insertion Reactions and Copolymerization Involving Palladium Complexes of a NiN2S2 Metallodithiolate Ligand.” Organometallics, 26 (4), 783-792.  

 

8.    Phelps, Andrea L.; Rampersad, Marilyn V.; Fitch, Shawn B.; Darensbourg, Donald J.; Darensbourg, Marcetta Y. (2006) “Kinetic Study of the Ring-Opening Process in Tungsten Carbonyl Complexes Containing Hemilabile Metallodithiolate Ligands.” Inorganic Chemistry, 45 (1), 119-126.

 

9.     Jeffery, Stephen P.; Green, Kayla N.; Rampersad, Marilyn V.; Darensbourg. Marcetta Y. (2006)NiN2S2 Complexes as Metallodithiolate Ligands to RhI, RhII and RhIII.” Dalton Transactions, 35, 4244-4252.

 

10.  Rampersad, Marilyn V.; Jeffery, Stephen P .; Golden, Melissa L.; Lee, Jonghyuk; Reibenspies, Joesph H.; Darensbourg, Donald J.; Darensbourg, Marcetta Y. (2005) “Characterization of Steric and Electronic Properties of NiN2S2 Complexes as S-Donor Metallodithiolate Ligands.” Journal of the American Chemical Society, 127(49), 17323-17334.

 

11.  Rampersad, Marilyn V.; Jeffery, Stephen. P.; Reibenspies, Joesph H.; Ortiz, Cesar G.; Darensbourg, Donald J.; Darensbourg, Marcetta Y. (2005) “N2S2Ni Metallothiolates as a Class of Ligands that Support Organometallic and Bioorganometallic  Reactivity.” Angew. Chem., Int. Ed., 44, 1217-1220.

 

12.  Golden, Melissa L.; Whaley, Curtis M.; Rampersad, Marilyn V.; Reibenspies, Joseph  H.; Hancock, Robert D.; Darensbourg, Marcetta Y. (2005) “N2S2Ni Metallodithiolate Complexes as Ligands: Structural and Aqueous Solution Quantitative Studies of the Ability of Metal Ions to Form M-S-Ni Bridges to Mercapto Groups Coordinated to Nickel(II): Implications for Acetyl coA Synthase.” Inorganic Chemistry, 44(4), 875-883.

 

13.  Golden, Melissa L.; Rampersad, Marilyn V.; Reibenspies, Joseph H.; Darensbourg, Marcetta Y. (2003) “Capture of NiII, CuI and ZnII by Thiolate Sulfurs of an N2S2Ni complex: A role for a Metallothiolate Ligand in the Acetyl-coenzyme A Synthase Active Site.” Chemical Communications, 15, 1824-1825.

 

14.  Zhao, Xuan; Chiang, Chao-Yi; Miller, Mathew L.; Rampersad, Marilyn V.; Darensbourg, Marcetta Y. (2003) "Activation of Alkenes and H2 by [Fe]-H2ase Model Complexes.” Journal of the American Chemical Society, 125, 518-524.

 

15.  Efange, Simon M. N.; Tu, Zhude.; von Hohenberg, Krystyna.; Francesconi, Lynn C; Howell, Roberta  C.; Rampersad, Marilyn V.; Todaro, Luis. J.; Papke, Roger. L.; Kung, Mei-Ping. (2001) “2-(2-Piperidyl)- and 2-(2-Pyrrolidyl)chromans as Nicotine Agonists: Synthesis and Preliminary Pharmacological Characterization.”  Journal of Medicinal Chemistry, 44, 4704-4715.

 

Presentations

1.    253rd American Chemical Society Meeting, April 2nd, 2017, San Francisco, CA. Miesen, T. J. and Mackiewicz, M. R “Hybrid Lipid-coated Silver Nanoparticles Differentially Shielded from Ag ion Release(Poster)

 

2.    252nd American Chemical Society Meeting, August 21st, 2016, Philadelphia, PA. Grant M. Marquart and Mackiewicz, M. RSurface Modification of Gold Nanorods as Enhanced Contrast Agents for in vivo Optical Coherence Tomography Imaging” (oral presentation)

 

3.    251sh American Chemical Society Meeting, March 15th, 2016, San Diego, CA. Sanchez, P. and Mackiewicz, M. R.Robust Hybrid Membrane-coated Nanoparticles for Targeting Tumors” (Poster)

 

4.    248th American Chemical Society Meeting, March 22 & 23, 2015, Denver, CO.  Costa, Erica A.; Jorgenson, Brent D.; Mackiewicz, Marilyn R. "Modulating Beta-Amyloid Aggregation with Metal Ions and Nanochelators".

 

5.    Society for Neuroscience Oregon Chapter Meeting, March 28, 2015, Portland, OR. Marquart, G. W.; Miesen, T. J.; and Mackiewicz, M. R. “Biomimetic Membrane-coated Nanomaterials for Bioimaging and Protein Sensing” (Poster presentation).

 

6.    Sigma Xi Columbia-Willamette Student Research Symposium, April 16, 2015, Portland, OR. Marquart, G. W.; Miesen, T. J.; and Mackiewicz, M. R. “Biomimetic Membrane-coated Nanomaterials for Bioimaging and Protein Sensing” (Poster presentation, first place awarded for best poster).

 

7.    Sigma Xi Columbia-Willamette Student Research Symposium, April 16, 2015, Portland, OR. Jorgenson, B. D.; Ajjarapu, R. and Mackiewicz, M. R. “Gold Nanoparticles as Heavy Metal Ion Capture Agents for Alzheimer’s Disease and Cancer”

 

8.    Ronald E. McNair Scholars, Feb 14, 2014, Portland, OR. Mackiewicz, M. R. “A Guide to Development of Scientific Methodology” (Oral presentation).

 

9.    Lois Stokes National Alliance for Minority Participation, Feb 16, 2014, Portland, OR. Mackiewicz, M. R. “A Scientist First, then a Minority: Using Your Diversity as Motivation to Lead Interdisciplinary Research” (Oral presentation).

 

10. 247th American Chemical Society Meeting, March 16th, 2014, Dallas, TX. Nguyen, Tan; Mackiewicz, Marilyn Rampersad. “Nanochelators for sensing and targeting iron in cancer cells (poster)

 

11. 247th American Chemical Society Meeting, March 16th, 2014, Dallas, TX. Clifton, Molly; Mackiewicz, Marilyn Rampersad. “Site-directed nanochelators for reversing metal-induced protein aggregation (poster)

 

12. Society for Neuroscience Oregon Chapter Meeting April 4th, 2014, Portland, OR. Clifton, Molly; Frost, D. C.; Aier, S. C.; Keller, J. R. Stanek, J. W.  Mackiewicz, Marilyn Rampersad. “Modulating beta amyloid aggregation with metal Ions and chelators. (poster)

 

13. 10th annual Sigma Xi Columbia-Willamette Student Research Symposium, April 15, 2014, Portland, OR. Nguyen, T. P.; Mackiewicz, M. R. “Monitoring iron uptake onto gold nanoparticle surfaces for use as theranostic agents in cancer therapy” (Poster presentation, Second place awarded for best poster).

 

14. 2014 Pacific Northwest McNair/EIP/GO-MAP Research Conference, May 16, 2014, Seattle, WA. Nguyen, T. P.; Mackiewicz, M. R. “Monitoring iron uptake onto gold nanoparticle surfaces for use as theranostic agents in cancer therapy” (Poster presentation).

15. 246th American Chemical Society Meeting, September 8th, 2013, Indianapolis, IN. Mackiewicz, Marilyn Rampersad. “Effect of metal ions and chelators in modulating beta amyloid aggregation and binding to biomimetic lipid-coated gold nanoparticles” (Oral presentation)

 

16. 242nd American Chemical Society Meeting, August 29th, 2011, Denver, CO. Mackiewicz, Marilyn Rampersad. “Biocompatible nanochelators surface functionalized with phytochelatin peptide derivatives for metal chelation studies.” (Oral presentation)

 

17. NORM172 ACS Northwest Regional Meeting, June 29th, 2011, Portland , OR. Mackiewicz, Marilyn Rampersad. “Phytochelatin-based Gold Nanochelators for Metal Ion Detection and Chelation Studies” (oral presentation)

 

18. 241st American Chemical Society Meeting, March 29th, 2011, Anaheim, CA. Mackiewicz, Marilyn Rampersad, Ho Wu, Rosina; Mau, Theresa; Azimi, Shauyaun; and Sinche, Federico. “Multifunctional biocompatible iron and gold nanomaterials for metal chelation applications.” (poster presentation)

 

19. Seminar at Oregon State University, February 9th, 2011, Corvallis, OR. Mackiewicz, Marilyn Rampersad. “Nanoparticles as Mimics of Biological Membrane Structures.” (oral presentation)

 

20. Seminar at Colorado School of Mines and NREL, March 9th, 2010, Golden, CO. Mackiewicz, Marilyn Rampersad; Reed, S. M. “Designing Nanoscale Architectures for Nanosensor Development.” (oral presentation)

 

21. 238th American Chemical Society Meeting, August 15th, 2009, Washington , DC. Mackiewicz, Marilyn Rampersad; Reed, Scott M. “C-reactive Protein Recognition by Phosphatidylcholine-stabilized Gold Nanoparticles.” (poster presentation)

 

22. Seminar at Michigan State University, January 26th, 2009, Lansing, MI. Mackiewicz, Marilyn Rampersad; Reed, S. M. “Nanoparticles as Mimics of Biological Membrane Structures for Detection of C-Reactive Protein. (oral presentation)

 

23. Seminar at University of Colorado at Denver, January 29th, 2009, Denver, CO. Mackiewicz, Marilyn Rampersad; Reed, S. M. “Nanoparticles as Mimics of Biological Membrane Structures for Detection of C-Reactive Protein. (oral presentation)

 

24. Seminar at University of Texas at San Antonio, February 3rd, 2009, San Antonio, TX. Mackiewicz, Marilyn Rampersad; Reed, S. M. “Nanoparticles as Mimics of Biological Membrane Structures for Detection of C-Reactive Protein. (oral presentation)

 

25. 3rd Annual Greener Nanoscience, March 10th, 2008, Hewlett-Parkard, Corvallis, OR. Mackiewicz, Marilyn Rampersad; Sitaula, Sarita; Ayres, Benjamin R.; Reed, Scott M. “Lecithin-stabilized Gold Nanoparticles with Unique Phase Transfer Properties and their Reactivity to Thiol Exchange.” (poster presentation)

 

26. Hunter College Recruitment Seminar, October 26th, 2008. Hunter College, New York, NY. Rampersad, Marilyn V. “Development of NiN2S2 Complexes as Bidentate Ligands for Organometallic Chemistry.” (oral presentation)

27. International Conference on Biological Inorganic Chemistry, July 31st, 2005. Ann Arbor, Michigan. Rampersad, Marilyn V.; Darensbourg, Marcetta Y. “Bioinspired Metallodithiolate Ligands To facilitate C-C Coupling Reactions at Palladium.” (poster presentation). 

 

28. 229th American Chemical Society Meeting, March 13, 2004, San Diego, CA.  Rampersad, Marilyn V.; Jeffery, Stephen P.  Golden, Melissa L.; Ortiz, Cesar G.; Darensbourg, Donald J.; Darensbourg, Marcetta Y. “Development of Metal  Dithiolate Complexes as Bidentate Ligands for Organometallic Chemistry Inspired by Acetyl Coenzyme A Synthase.” (poster presentation)

 

29. Industry-University Cooperative Chemistry Program IUCCP Symposium, October 18, 2004, Texas A & M University, College Station, TX. Rampersad, Marilyn V.; Jeffery, Stephen P.; Golden, Melissa L.; Darensbourg, Marcetta Y. (award winner best oral presentation). “Development of Metal Dithiolate Complexes as Bidentate Ligands for Organometallic Chemistry: Inspired by Acetyl coA Synthase.” (award winner best oral presentation)

 

30. Chemistry and Biology Interface Conference, August 21, 2004, Texas A & M University, College Station, TX. Rampersad, Marilyn V.; Jeffery, Stephen P.; Golden, Melissa L.; Darensbourg, Marcetta Y. “Development of Metal Dithiolate Complexes as Bidentate Ligands for Organometallic Chemistry: Inspired by Acetyl coA Synthase.” (oral presentation)

 

31. 36th International Conference on Coordination Chemistry, July 18-23, 2004, Mérida, Yucatán, México. Rampersad, Marilyn V.; Jeffery, Stephen P.; Golden, Melissa L.; Darensbourg, Marcetta Y. “Development of Metal Dithiolate Complexes as Bidentate Ligands for Organometallic Chemistry.” (poster presentation)

 

32. 225th American Chemical Society Meeting, March 25, 2004, New Orleans, LA. Rampersad, Marilyn V.; Darensbourg, Marcetta Y.; Miller, Matthew L.   “Synthesis and Structural Characterization of Heteronuclear Clusters Comprised of Nickel and Copper Bridged by Thiolates.” (poster presentation)

 

33. Pacifichem 2000 Conference, December 14, 2000, Honolulu, Hawaii.  Rampersad, Marilyn V.; Howell, Roberta.; Francesconi, Lynn. C. “Contrasting Reactive Properties of Rhenium and Technetium with Cyclic Metaphosphates and the Phosphate Based Polyoxotungstate P2W17O61]-10.” (Award winner best poster presentation)