Research



Justin Courcelle
Portland State University
Department of Biology
P.O. Box 751
Portland, Oregon
97207-0751
justc@pdx.edu
http://web.pdx.edu/~justc

503 725-3866 office
503 725-3865 lab
503 725-3888 fax

SRTC Building rm b2-04
    

  Research in our laboratory focuses upon the fundamental "rules" which operate to maintain genomic stability in the cell. During cellular replication, whether in bacterial or human cells, each chromosome is processively replicated in its exact linear order until the precise point when the genomic template has been duplicated. As a cancer biologist, I am interested in how this fundamentally conserved process is regulated and maintained. Through these studies, I also hope to understand the molecular events which can lead this normally faithful process of duplication to sometimes become less than perfect.

Some of our recent research has concentrated upon how the DNA replication machinery accurately duplicates the chromosomal material when some of the genetic information has been damaged by exposure to UV-irradiation. Inaccurate replication caused by DNA damage is believed to produce most of the genomic rearrangements and mutations which can lead to cancer. Our laboratory uses a variety of molecular and cellular techniques to identify how the cell is able to repair and replicate the damaged DNA without errors, such that these mutagenic consequences can be avoided.


Frontiers in Bioscience


 University of Vermont

Stanford University

 University Rene Descartes

Mississippi State University

 Portland State University

 

Research in our lab is supported by CAREER award MCB0448315 from the National Science Foundation

 

and National Research Service Award NIGMS 5F32GM068566 to Charmain Courcelle from the National Institutes of Health


The views and opinions expressed in this page are strictly those of the page author. The contents of this page have not been reviewed or approved by Portland State University