Keith D. Garlid Received 17 July 1978. Unmasking the mitochondrial K/H exchanger: Swelling-induced K+-loss

Abstract:

Matrix swelling induces a rapid, transient, energy-independent potassium efflux in rat liver mitochondria. Swelling-induced K+-loss is electroneutral; therefore it does not reflect electrophoretic diffusion secondary to increased membrane permeability. Matrix swelling unmasks an endogenous K/H transport mechanism in the mitochondrial membrane, providing a valuable experimental approach to the study of K+ transport in mitochondria.


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