Publications
Journal Articles
• GE Ice, GS Brown, GB Armen, MH Chen, B Craseman, JC Levin & DC Mitchell; Atomic Inner-Shell Threshold Excitation With Synchrotron Radiation.,
Am Inst Phys Proc., 94:105-113 (1982).
• DC Mitchell & GW Rayfield; The Order Of Proton Uptake And Release By Bacteriorhodopsin At Low pH, Biophysical Journal 49:563-566 (1986).
• M Straume, DC Mitchell, JL Miller & BJ Litman; Interconversion Of Metarhodopsin I And II: A Branched Photointermediate Decay Model,
Biochemistry 29:9135-9142 (1990).
• DC Mitchell, M Straume, JL Miller & BJ Litman; Modulation Of Metarhodopsin Formation By Cholesterol-Induced Ordering Of Bilayer Lipids,
Biochemistry, 29:9143-9149 (1990).
• DC Mitchell, M Straume, & BJ Litman; Modulation Of Integral Membrane Protein Conformational Equilibrium By Lipid Bilayer Physical Properties: Correlation Of The Metarhodopsin I To Metarhodopsin II Conformational Equilibrium With A Global Property Derived From DPH Fluorescence Anisotropy Measurements,
FASEB Proceedings (1990).
• J Kibelbek, DC Mitchell, JM Beach & BJ Litman; Functional Equivalence Of Metarhodopsin II And The Gt-Activating Form Of Photolyzed Bovine Rhodopsin,
Biochemistry 30:6761-6768 (1991).
• DC Mitchell, J Kibelbek & BJ Litman; Rhodopsin In Dimyristoylphosphatidylcholine Reconstituted Bilayers Forms Metarhodopsin II And Activates Gt.,
Biochemistry 30:37-42 (1991).
• DC Mitchell, J Kibelbek & BJ Litman; The Effect Of Phosphorylation On Receptor Conformation: The Metarhodopsin I : Metarhodopsin II Equilibrium In Multiply Phosphorylated Rhodopsin,
Biochemistry 31:8107-11 (1992).
An Accelerated Publication.
• DC Mitchell, M Straume & BJ Litman Role Of Sn-1 Saturated, Sn-2 Polyunsaturated Phospholipids In Control Of Membrane Receptor Conformational Equilibrium: Effects Of Cholesterol And Acyl Chain Unsaturation On The Metarhodopsin I : Metarhodopsin II Equilibrium.,
Biochemistry 31:662-670 (1992).,
• J Kibelbek, DC Mitchell & BJ Litman; The Mechanism Of Reduced Gt Activation By Phosphorylated Rhodopsin: The Effect Of Rhodopsin Phosphorylation On The Formation And Decay Of Metarhodopsin And Rhodopsin-Gt Interactions,
in Structures and Functions of Retinal Proteins , edited by J. L. Rigaud, INSERM/John Libbey (Paris), (1993).
• DC Mitchell & BJ Litman, Biochemistry; Effect Of Ethanol On Metarhodopsin II Formation Is Potentiated By Phospholipid Polyunsaturation,
Biochemistry 33:12752-12756 (1994).
An Accelerated Publication.
• DC Mitchell, JTR Lawrence & BJ Litman; Primary Alcohols Modulate The Activation Of The G Protein-Coupled Receptor Rhodopsin By A Lipid-Mediated Mechanism,
J Biol Chem. 271:19033 - 19036 (1996).
A Rapid Communication.
• BJ Litman & DC Mitchell; A Role For Phospholipid Polyunsaturation In Modulating Membrane Protein Function,
Lipids, 31: S193 - S197 (1996).
• DC Mitchell & BJ Litman; Molecular Order and Dynamics in Bilayers Consisting of Highly Polyunsaturated Phospholipids,
Biophys J., 74: 879-891 (1998).
• DC Mitchell, K Gawrisch, BJ Litman, & N Salem Jr.; Why is Docosahexaenoic Acid Essential for Nervous System Function?,
Biochem Soc Trans. 26:365-370 (1998).
• DC Mitchell & BJ Litman; Effect of Cholesterol on Molecular Order and Dynamics in Highly Polyunsaturated Phospholipid Bilayers,
Biophys J., 75:896-908 (1998).
• DC Mitchell & BJ Litman; The Phospholipid Bilayer Mediates the Effect of Primary Alcohols on Rhodopsin Activation, Essential Fatty Acids & Eicosanoids: Invited Papers from 4th Int. Conference, 154-158 (1998).
• DC Mitchell & BJ Litman; Docosahexaenoic Acid-Containing Phospholipids Optimally Promote Rhodopsin Activation., Essential Fatty Acids & Eicosanoids: Invited Papers from 4th Int. Conference, 336-340 (1998).
• DC Mitchell & BJ Litman; Effect of Protein Hydration on Receptor Conformation: Decreased Levels of Bound Water Promote Metarhodopsin II Formation,
Biochemistry 38:7617-7623 (1999).
An Accelerated Publication.
• DC Mitchell & BJ Litman; Effect of Ethanol and Osmotic Stress on Receptor Conformation: Reduced Water Activity Amplifies Ethanol’s Effect on Metarhodopsin II Formation.,
J Biol Chem., 275:5355-5360 (2000).
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• BW Koenig, DC Mitchell, BJ Litman, S Grzesiek & A Bax; Measurement of Dipolar Couplings in a Transducin Peptide Fragment Weakly Bound to Oriented Photo-activated Rhodopsin.
J Biomolecular NMR 16:121-125 (2000).
• BJ Litman, SL Niu, A Polozova, and DC Mitchell; The Role Of Docosahexaenoic Acid Containing Phospholipids In Modulating G Protein-Coupled Signaling Pathways: Visual Transduction.
J Mol Neurosci. 16: 153-158 (2001).
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• BG Jeffrey, HS Weisinger, M Neuringer, and DC Mitchell; The Role of Docosahexaenoic Acid in Retinal Function.
Lipids 36: 859-871 (2001).
• DC Mitchell, SL Niu, and BJ Litman; Optimization of receptor-G protein coupling I: kinetics of rhodopsin-transducin binding.
J Bio. Chem. 276: 42801-6 (2001).
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• SL Niu, DC Mitchell, and BJ Litman; Optimization of receptor-G protein coupling II: formation of the metarhodopsin II-transducin complex.
J Biol Chem. 276:42807-11 (2001).
• BG Jeffrey, DC Mitchell, RA Gibson, and M Neuringer; n-3 fatty acid deficiency alters recovery of the rod photoresponse in rhesus monkeys.
Inv Opth Vis Sci. 43:2806-14 (2002).
• BW Koenig, G Kontaxis, DC Mitchell, JM Louis, BJ Litman, and A Bax, Structure and orientation of a G protein fragment in the receptor bound state from residual dipolar couplings.
J Mol Biol. 322:441-461 (2002).
• SL Niu, DC Mitchell, and BJ Litman; Manipulation of cholesterol in rod disk membranes by methyl-β-cyclodextrin: effects on receptor activation.
J. Biol. Chem. 277:20139-201345 (2002).
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• HS Weisinger, JA. Armitage, BG Jeffrey, DC Mitchell, T Moriguchi, AJ Sinclair, RS Weisinger, and N Salem Jr., Retinal sensitivity loss in third-generation n-3 PUFA-deficient rats. Jr.
Lipids 37:759-765 (2002).
• BG. Jeffrey, DC Mitchell, JR Hibbeln, RA Gibson, AL Chedester, and N Salem Jr.,Visual acuity and retinal function in infant monkeys fed long-chain PUFA.
Lipids 37:839-848 (2002).
• HS Weisinger, DC Mitchell, and K Pesudovs, Reading the fine print: correcting ametropia in infant visual acuity studies.
Clin Exp Optom. 86:65-66 (2003).
• DC Mitchell, SL Niu, and BJ Litman, DHA-rich phospholipids optimize G protein-coupled signaling.
J Pediatrics 143:s80-s86 (2003).
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• DC Mitchell, SL Niu, and BJ Litman, Enhancement of G protein coupled signaling by DHA phospholipids,
Lipids 38:437-443 (2003).
• SL Niu, DC Mitchell, SY Lim, ZM Wen, HY Kim, N Salem Jr., and BJ Litman, n-3 deficiency in rats reduces G protein coupled signal transduction in retinal rod outer segment membranes.
J Biol Chem 279:31098-31104 (2004).
• SL Niu, DC Mitchell, and Burton J. Litman, Trans fatty acid derived phospholipids show increased membrane cholesterol and reduced activation as compared to their cis analogs.
Biochemistry 44:4458-4465 (2005).
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• SL Niu and DC Mitchell, Effect of packing density on rhodopsin stability and function in polyunsaturated membranes.
Biophysical Journal 74:879-891 (2005).
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• CE Ellis, EJ Murphy, DC Mitchell, MY Golovko, F Scaglia, and RL Nussbaum, Mitochondrial lipid abnormality and oxphos impairment in mice lacking α-synuclein. Submitted to
Molecular & Cellular Biology 25:10190-10201 (2005).
• CH Chen, HL Puhl, SL Niu, DC Mitchell and SR Ikeda, Expression of Rem2, an RGK family small GTPase, reduces N-type calcium current without affecting channel surface density.
Journal of Neuroscience 25(42):9762-9772 (2005).
• MP Bennett and DC Mitchell; Regulation of membrane proteins by dietary lipids: Effects of cholesterol and DHA-containing phospholipid on rhodopsin stability and function,
Biophysical Journal 95:1206-16 (2008).
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• O Soubias, SL Niu, DC Mitchell & K Gawrisch; Hydrophobic mismatch induces change in rhodopsin helical content but no change in membrane thickness.
Journal of the American Chemical Society 130:12465-71 (2008).
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• K Boesze-Battaglia, M Damek-Poprawa, DC Mitchell, L Greeley, RS Brush, RE Anderson, MJ Richards & SJ Fliesler; Alteration of Retinal Rod Outer Segment Membrane Fluidity in a Rat Model of Smith-Lemli-Opitz Syndrome.
Journal of Lipid Research 49:1488-99 (2008).
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• SR Shaikh, DC Mitchell, E Carroll, M Li, J Schneck & M Edidin; Differential effects of a saturated and monounsaturated fatty acid on MHC Class I antigen presentation.
Scand J. Immunol. 69:30-42 (2008).
• Cole NB, Dieuliis D, Leo P, Mitchell DC, Nussbaum RL; Mitochondrial translocation of alpha-synuclein is promoted by intracellular acidification.
Exp. Cell Res. 314:2076-89 (2008).
• SL Niu, B Doctrow and DC Mitchell; Rhodopsin Conformation Change Varies with Method of Proteoliposome Preparation;
Biochemistry 48:156-163 (2009).
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• GJ Turner, S Chittiboyina, L Pohren, KG Hines , JJ Correia and DC Mitchell. The bacteriorhodopsin carboxyl-terminus contributes to proton recruitment and protein stability.
Biochemistry, 48:1112-1122 (2009).
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Invited Reviews
• BJ Litman & DC Mitchell; Rhodopsin Structure And Function., pp. 1-32,
In Biomembranes Volume II, edited by A. Lee, JAI Press (New York), 1996.
• DC Mitchell & BJ Litman; Modulation of Receptor Signaling by Phospholipid Acyl Chain Unsaturation., pp. 41-62.
In Fatty Acids: From Neuronal Membranes to Physiological and Behavioral Function, edited by D. I. Mostofsky, S. Yehuda, & N. Salem Jr., Humana Press (Totowa N.J.), 2001.