CURRENT RESEARCH PROJECTS
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PUBLICATIONS
El Yacoubi, B., Hatin, I., Deutsch, C., Kahveci, T., Rousset, J-P., Iwata-Reuyl, D., Murzin, A., and de Crécy-Lagard, V. "A role for the universal Kae1/Qri7/YgjD (COG0533) family in tRNA modification." In press, EMBO J.
Phillips, G., Chikwana, V. M., Maxwell, A., El-Yacoubi, B., Swairjo, M. A., Iwata-Reuyl, D. and de Crécy-Lagard, V. "Discovery and characterization of an amidinotransferase involved in the modification of archaeal tRNA." J. Biol. Chem. 2010, 285:17, 12706-12713.
Sankaran, B.; Bonnett, S.; Shah, K.; Gabriel,S.; Reddy, R.; Schimmel, P.; Rodionov, D. A.; de Crécy-Lagard, V.; Helmann, J. D.; Iwata-Reuyl, D.; Swairjo, M. A. "Zinc-independent folate biosynthesis: genetic, biochemical, and structural investigations reveal new metal dependence for GTP Cyclohydrolase IB," J. Bacteriol.,2009, 191, 6939-6949.
Iwata-Reuyl, D., and de Crécy-Lagard, V. 2009. "Enzymatic Formation of the 7-Deazaguanosine Hypermodified Nucleosides of tRNA," pp. 377-391. InDNA and RNA Modification Enzymes: Structure, Mechanism, Function and Evolution, Henri Grosjean, Ed. Landes Bioscience, Austin, Tx.
Phillips, G.; El Yacoubi, B.; Lyons, B.; Alvarez, S.; Iwata-Reuyl, D.; de Crécy-Lagard, V. "The biosynthesis of the 7-deazaguanosine modified tRNA nucleosides: a new role for GTP cyclohydrolase I," J. Bacteriol., 2008, 190, 7876-7884.
Iwata-Reuyl, D. "An Embarassment of Riches: The enzymology of tRNA modification," Current Opinion in Chemical Biology, 2008,12, 126-133.
Lee, B.; Van Lanen, S. G.; Iwata-Reuyl, D. "Mechanistic studies of QueF, the nitrile oxidoreductase involved in the biosynthesis of queuosine," Biochemistry,2008, 46, 12844-12854.
Roth, A.; Winkler, W. C.; Regulski, E.; Lee, B.; Lim, J.; Jona, I.; Barrick, J. E.; Ritwik, A.; Kim, J.; Welz, R.; Iwata-Reuyl, D.; Breaker, R. R. "A eubacterial riboswitch selective for the queuosine precursor preQ1 contains an unusually small aptamer domain," Nature Struct. Mol. Biol., 2007, 14, 308-317.
El Yacoubi, B.; Bonnett, S.; Anderson, J.; Swairjo, M. A.; Iwata-Reuyl, D. and de Crécy-Lagard, V. "Discovery of a new prokaryotic type I GTP cyclohydrolase family," J. Biol. Chem., 2006, 281(49), 37586-37593.
Swairjo, M. A.; Reddy, R. R.; Lee, B.; Van Lanen, S. G.; Brown, S.; de Crécy-Lagard, V.; Iwata-Reuyl, D.; and Schimmel, P. "Crystallization and preliminary X-ray characterization of the nitrile reductase QueF–a queuosine biosynthesis enzyme," Acta Cryst., 2005, F61, 945-948.
Overbeek, R., et al. "The Subsystems Approach to Genome Annotation and its Use in the Project to Annotate 1,000 Genomes," Nucleic Acids Res., 2005, 33(17), 5691-5702.
Van Lanen, S. G.; Reader, J. S.: Swairjo, M. A..; de Crécy-Lagard, V.; Lee, B.; Iwata-Reuyl, D., "From cyclohydrolase to oxido-reductase: Discovery of nitrile reductase activity in a common fold," Proc. Natl. Acad. Sci. USA, 2005, 102:12, 4264-4269.
Van Lanen, S.; Iwata-Reuyl, D., "Kinetic Mechanism of the tRNA Modifying Enzyme S-Adenosylmethionine:tRNA Ribosyltransferase-isomerase (QueA)," Biochemistry, 2003, 42:18, 5312-5320.
Van Lanen, S.; Daoud Kinzie, S.; Matthieu, S.; Link, T.; Culp, J.; Iwata-Reuyl, D., "tRNA Modification by S-Adenosylmethionine:tRNA Ribosyltransferase-isomerase (QueA): Assay Development and Characterization of the Recombinant Enzyme," J. Biol. Chem., 2003, 278:12, 10491-10499.
Iwata-Reuyl, D., "The Biosynthesis of the 7-Deazaguanosine Hypermodified Nucleosides of Transfer RNA," Bioorg. Chem., 2003, 31, 24-43.
Bai, Y.; Fox, D.; Lacy, J.; Van Lanen, S.; and Iwata-Reuyl, D. "Hypermodification of tRNA in Thermophilic Archae: Cloning, Over-Expression, and Characterization of tRNA-Guanine Transglycosylase from Methanococcus jannaschii," J. Biol. Chem., 2000, 275:37, 28731-28738.
Daoud Kinzie, S.; Thern, B.; Iwata-Reuyl, D. "Mechanistic Studies of the tRNA-Hypermodifying Enzyme QueA: A Chemical Imperative for the Use of AdoMet as a 'Ribosyl' Donor," Org. Lett. 2000, 2, 1307-1310.
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